Clinical effect of rivarxocaban in the treatment of acute exacerbation of chronic obstructive pulmonary disease
ZHANG Jin-chao
WANG Jin-rong
LIU Shu-hong
CUI Zhao-bo
ZHANG Hui-juan
Abstract：Objective To discuss the clinical effect of rivarxocaban in the treatment of acute exacerbations of the acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods One hundred and twenty cases with AECOPD from March 2011 to March 2013 were randomly divided into observation group (60 cases) and control group(60 cases).Both groups received conventional treatment including antibiotics,bronchodilator,phlegm removing and continuous low-flow oxygen inhalation.The observation group received rivarxocaban take orally(10 mg) per 24 hours for 7 days of two groups were observed.Results The total effective rate of the observation group was 83.3％ (50/60),which was higher than that in control group (53.3％,32/60),the average hospitalization time of the observation group was (10.5 ± 2.4) d,which was shorter than (18.5 ± 5.6) d in control group (P ＜ 0.01).Compared with control group,the observation group's blood coagulation and blood gas analysis were improved (P ＜0.01 or P＜0.05).D-eimer level dropped,the difference was significant(P＜0.01).Conclusion Rivarxocaban has a definite effect on AECOPD and it can effectively improve the blood hypercoagulable state and clinical symptoms,alleviate the inflammation reaction and defer the worsening of illness.
Keywords：Pulmonary disease,chronic obstructiveAcute exacerbationRivarxocaban
Publication Date：2013-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 1703-1704 )