Clinical observation on gemfibrozil combined with low doses of simvastatin in the treatment of elderly patients with primary mixed hyperlipidemia
HAO Yun-ling
WU Hong-ling
Abstract：Objective To observe the clinical efficacy of gemfibrozil combined with low doses of Simvastatin in the treatment of elderly patients with primary mixed hyperlipidemia.Methods One hundred and fifty elderly patients with primary mixed hyperlipidemia (age ≥65 years) in the second people's hospital of Futian district in Shenzhen city from July 2010 to December 2012 were randomly divided into control group (75 cases) and the observation group (75 cases) by the random number table.The control group received simvastatin 20 mg/d.The observation group received gemfibrozil (300-600 mg/d) and simvastatin (10 mg/d).After six weeks,the total effective rate,total cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C),high-density lipoproteincholesterol (HDL-C) and blood pressure of two groups were compared.Results After 6 weeks of treatment,the total effective rate of observation group was 98.7％ while the control group was 92.0％ ; the difference was statistically significant (P ＜ 0.05).There were significant differences on TC,TG,LDL-C,HDL-C levels between two groups [observation group:(4.6 ± 0.5),(1.2 ± 0.3),(2.4 ± 0.6),(1.5 ± 0.3) mmol/L; contiol group:(4.9 ± 0.4),(1.6 ± 0.3),(3.0 ± 0.5),(1.0 ± 0.3) mmol/L] after treatment compared with those before treatment [observation group:(7.1 ± 0.6),(2.3 ± 0.3),(4.1 ± 0.4),(0.9 ± 0.4) mmol/L; control group:(7.0 ± 0.6),(2.3 ± 0.3),(4.1 ± 0.4),(0.9 ± 0.4) mmol/L] (P ＜ 0.05).There were significant differences on TC,TG,LDL-C,HDL-C levels of observation group after treatment compared with control group (P ＜ 0.05).After treatment,systolic blood pressure and diastolic blood pressure of two groups [observation group:(132 ± 7),(83 ± 6)mm Hg; control group:(140 ± 6),(87 ± 6) mm Hg] were lower than before treatment [observation group:(156 ± 10),(97 ± 8) mm Hg; control group:(157 ± 8),(96 ± 6) mm Hg] (P ＜ 0.05).There were significant differences on systolic blood pressure and diastolic blood pressure of observation group compared with control group (P ＜ 0.05).Conclusions Gemfibrozil combine with low dose simvastatin is effective for the elderly patients with primary mixed hyperlipidemia.It can reduce the level of TC,TG,LDL-C,increase the level of HDL-C and effectively improve the patient's blood pressure.
Keywords：Primary mixed hyperlipidemiaGemfibrozilSimvastatin
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1539-1541 )