Prediction value of levels of peripheral regulation T cells on long-term efficacy of adefovir dipivoxil antiviral treatment in patients with chronic hepatitis B

SHI Wei-tao; WANG Qin-ying; ZHAO Xue; ZHAO Long-feng

doi:10.3760/cma.j.issn.1673-4777.2013.10.023

Abstract：Objective To investigate the relation between levels of regulation T cells (Treg cells) of peripheral blood in chronic hepatitis B (CHB) patients before receiving adefovir dipivoxil (ADV) antiviral therapy and the long-term clinical antiviral efficacy.Methods CHB patients with antiviral therapeutic indications and initial treatment of nucleoside analogues were selected as the case group ; healthy subjects served as the control group.The levels of Treg cells of peripheral blood in the case group before receiving ADV antiviral therapy and the control group were detected by flow cytometry.The case group was given ADV 10 mg/d antiviral treatment and examined regularly on HBV markers,HBV DNA and liver function etc.Results All 92 cases were divided into complete response,response and nonresponse on the basis of its efficacy.The levels of peripheral Treg cells in the 92 cases before receiving ADV antiviral therapy was significantly higher than those in the control group [(8.23 ± 5.2) ％ vs (3.0 ±0.7) ％,P ＜ 0.05].The levels of peripheral Treg cells in the no response group was significantly higher than those in the partial response group,the complete response group and the control group [(11.6 ± 1.6) ％ vs (5.6 ±1.3) ％,(3.6 ± 0.8) ％,(3.0 ± 0.7) ％] (P ＜ 0.01).Those in partial response group was significantly higher than those in healthy control group(P ＜ 0.01).But the levels of Treg cells in the complete response group and the control group were not significantly different (P ＞ 0.05).Conclusion Levels of Treg cells of peripheral blood in CHB patients before receiving ADV antiviral therapy have some predictive value for the long-term efficacy of ADV antiviral treatment.