Metergasis of pancreas on type 2 diabetes mellitus patients after intensive insulin therapy
XU Lin
XIAO Zheng-hua
CHEN Ding-yu
Abstract：Objective To monitor the serum insulin (INS),C-peptide (C-P),glucagon (GLC) and somtostatin (SS) levels among the type 2 diabetes mellitus (T2DM) patients receiving intensive insulin therapy in order to find out pathogenesis of T2DM.Methods All 40 T2DM patients and 19 healthy subjects were divided into T2DM group and NC group.All subjects had been fasting for 10 hours,and received oral 75 g glucose at 07:00.Then blood glucose,serum insulin,C-peptide,glucagon and somtostatin level was sampled at baseline,30 minutes and 120 minutes post oral glucose intake.The levels of blood glucose,INS,C-P,GLC and SS were compared among the 2 groups statistically.The T2DM had been examined again after intensive insulin therapy.Results ① Compared to NC group,the levels of blood glucose at 0,30,120 min increased significantly in T2DM group before treatment and after treatment(all P ＜0.01).After treatment,the levels of G0,G30 in T2DM group were lower than those before treatment [(7.8 ± 0.5) mmol/L vs (12.0 ± 1.7) mmol/L,(19.6 ± 4.7) mmol/L vs (23.4 ± 5.8) mmol/L,P ＜ 0.05 or P ＜ 0.01].②Before and after treatment,the levels of INS0,INS30 in T2DM group were lower than those in NC group,and the levels of INS120 were higher than those in NC group (P ＜ 0.05 or P ＜ 0.01).The levels of INS120 after treatment were higher than those before treatment in T2DM group[(175 ± 88) pmol/L vs(129 ±58)pmol/L,P ＜0.01].Compared to NC group,the levels of C-P in T2DM group before and after treatment were lower(all P ＜ 0.01).③ Before and after treatment,the levels of GLC in T2DM group were higher than those in NC group,and the levels of GLC after treatment were lower than those before treatment in T2DM,and there were significant differences(all P ＜0.01).④ Before and after treatment,the levels of SS0,SS120 in T2DM group were higher than those in NC group[(89 ±9),(89 ± 8)ng/L vs (83 ± 12)ng/L,(107 ±14),(109 ± 12)ng/L vs(96 ± 16)ng/L],and the levels of SS3o were lower than those in NC group [(110 ± 13),(109 ± 13) ng/L vs (119 ± 19) ng/L],and there were significant differences(P ＜0.05 or P ＜0.01).Conclusions The β-cell function is damaged in T2DM patients.The α-cell function is impaired and GLC can not be restrained by hyperglycaemia.The γ-cell function is impaired and secretion peak is deficient.Short-time intensive insulin therapy can improve β-cell and α-cell function.
Keywords：Type 2 diabetes mellitusInsulinGlucagonSomtostatin
Publication Date：2013-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1410-1412 )