Serum soluble inerleukin-2 receptor, soluble tumor necrosis factor receptor Ⅱ levels in diagnosing pulmonary sarcoidosis activity
WANG Cai-cai
HUANG Yan
LU Cong-zhe
JIANG Yi
TIAN Guang
DUAN Yun-you
Abstract：Objective To detect serum soluble inerleukin-2 receptor (sIL-2R),soluble tumor necrosis factor receptor Ⅱ (sTNFR Ⅱ) and angiotensin converting enzyme (ACE) levels in active pulmonary sarcoidosis patients and normal human; to evaluate the value of sIL-2R,sTNFR Ⅱ in pulmonary sarcoidosis activity.Methods Of 52 cases with pulmonary sarcoidosis,28 cases were in active period,24 cases were in inactive period.Serum sIL-2R and sTNFR Ⅱ were detected by enzyme linked immunosorbent assay.Serum ACE level was determined by ultraviolet spectrophotometry and compared with 30 healthy volunteers.Results The serum sIL-2R and sTNFR Ⅱ of patients with active pulmonary sarcoidosis were (1.3 ± 0.6),(0.95 ± 0.29) μg/L and significantly higher than those in control group and patients with inactive sarcoidosis [(0.9 ± 0.4),(0.71 ± 0.21) μg/L and (0.9 ± 0.4),(0.77 ± 0.32) μg/L,respectively],and there were significant differences (P ＜ 0.05).There was no significant difference between patients with sarcoidosis in the inactive period and healthy volunteers(P ＞0.05).There was a correlation between the level of ACE and sIL-2R in patients with active pulmonary sarcoidosis (r =0.869,P ＜ 0.01),but there was no correlation between the levels of ACE and sTNFR Ⅱ (r =0.103,P ＞ 0.05).Conclusion The sIL-2R and sTNFR Ⅱ levels may serve as the indexes of sarcoidosis activity in order to guide the clinical treatment.
Keywords：SarcoidosispulmonaryActivitySoluble inerleukin-2 receptorSoluble tumor necrosis factor receptor ⅡImmunity
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1393-1395 )