Relationship between vitamin D receptor gene rs7975232 single nucleotide polymorphism and lung cancer risk
LI Rong
LOU YU-qing
YAN Bo
MA Mei-li
PEI Jun
HAN Bao-hui
Abstract：Objective To reveal the relationship between vitamin D receptor (VDR) gene rs7975232 single nucleotide polymorphism (SNP) and lung cancer risk in Chinese Han population.Methods A total of 72 patients with lung cancer and 67 healthy controls were in this study.SNP loci were detected by direct sequencing,sequencing by ABI3700XL Genetic Analyzer.Results VDR gene rs7975232 locus allele A carriers risk of lung cancer was significandy lower than the C allele carriers [odds ratio (OR) =0.501,95％ confidence interval (CI) =0.273-0.920,P =0.026].rs7975232 locus may be associated with squamous cell carcinoma [allele ratio:P =0.027,0R =0.274,95％ CI(O.087-0.861) ; dominant gene model:P =0.045,OR =0.269,95％ CI(0.074-0.971)].Conclusion VDR gene the rs7975232 locus is related to lung cancer pathogenesis.
Keywords：Lung cancerVitamin D receptorSingle nucleotide polymorphism
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1390-1392 )