The research of efficacy and safety of rosuvastatin calcium for the treatment of hypercholesterolemia
ZENG Xiang-guang
KONG Yue-qiong
HUANG Hong-qian
WANG Da-ping
Abstract：Objective To research the efficacy and safety of rosuvastatin calcium for the treatment of hypercholesterolemia which can provide reference to drug safety.Methods Totally 129 patients who met the inclusion criteria from December 2011 to December 2012 were enrolled and divided into three groups.43 patients of group A were treated with small doses of rosuvastatin calcium for 5 mg.43 patients of group B were given 10mg rosuvastatin calcium.43 cases of the control group were treated with atorvastatin calcium for 10 mg.After 12 weeks,the adverse reactions of the three groups were observed.Results After 12 weeks,the LDL-C of group A,group B and group C were lower 2.16 mmol/L,2.26 mmol/L and 1.8 mmol/L.TC were 2.21 mmol/L,2.28 mmol/L,1.79 mmol/L,lower than before treatment (P ＜ 0.05).The HDL-C of three groups was significantly higher than that before treatment.TG was significantly lower than before treatment (P ＞ 0.05).Group A and group B had no significant adverse reactions.But the control group had one case of aspartate aminotransferase.The adverse reaction rate was 4.65％.The difference was significant (P ＞ 0.05).Conclusion Rosuvastatin calcium can effectively reduce the LDL-C and TC of hypercholesterolemia.
Keywords：RosuvastatinHypercholesterolemiaEfficacySafety
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 1388-1389 )