Evaluation of endothelial function of bisoprolol on hypertension patients with heart failure
QI Zhi
JIANG Chang-liang
Abstract：Objective To investigate the endothelial function of bisoprolol on hypertension patients with heart failure.Methods A total of 80 patients with hypertension and heart failure were divided into two groups:40 cases with regular treatment as a control group and 40 cases with regular treament and bisoprolol as a treatment group.The blood pressure and heart rate were observed and the heart function was evaluated before and after treatment.Vascular endothelial function indicators such as vascular endothelial growth factor (VEGF),endothelin-1 (ET-1),nitric oxide (NO) and tumor necrosis factor-α (TNF-α) of two groups were compared.Results Both groups had a lower systolic blood pressure,diastolic blood pressure and heart rate after treatment [control group:(135 ±13)mm Hg (1 mm Hg=0.133 kPa) vs (156±12)mm Hg,(86 ±4)mm Hg vs (96±8)mm Hg,(64 ±7) times/min vs (74 ± 7) times/min ; treatment group:(133 ± 11) mm Hg vs (155 ± 14) mm Hg,(85 ± 4) mm Hg vs (97 ± 7) mm Hg,(64 ± 7) times/min vs (74 ± 7) times/min,P ＜ 0.05 or P ＜ 0.01].The levels of ET-1,VEGF and TNF-α in control group and treatment group after treatment were lower than those before treatment [control group:(76 ± 14)ng/L vs (87 ±20)ng/L,(121 ±20)vs (150 ±26),(36 ± 8) μg/L vs (41 ±7) μg/L; treatment group:(69 ± 18)ng/L vs (88 ± 18)ng/L,(120 ±20)ng/L vs (148 ±27)ng/L,(25 ±7) μg/L vs (41 ±8) μg/L],and the level of NO was higher than that before treatment[control group:(74 ± 21) μmol/L vs (65 ± 19) μmol/L;treatment group:(86 ± 23) μmol/L vs (65 ± 21) μmol/L] ; there were significant differences (P ＜ 0.05 or P ＜0.01).After treatment,the levels of ET-1,TNF-α in treatment group were lower than those in control group,and the level of NO in treatment group was higher than that in control group,there were significant differences(P ＜ 0.05 or P ＜ 0.01).Conclusion Bisoprolol has good effect on hypertension patients with heart failure and it can improve endothelial dysfunction.
Keywords：BisoprololHypertensionHeart failureEndothelial function
Publication Date：2013-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1383-1385 )