Effect of medroxyprogesterone acetate combined with DCF regimen chemotherapy on life quality of patients with advanced gastric cancer
CHEN Xiang-mei
LI Jin-yun
LIU Tai-feng
Abstract：Objective To observe the effect of medroxyprogesterone acetate (MPA) combined with DCF (docetaxel,cisplatin,fluorouracil)regimen chemotherapy on improving life quality of patients with advanced gastric cancer (AGC).Methods All 42 cases with AGC were randomly divided into DCF group treated only by chemotherapy,and MPA combined with DCF group treated only by MPA combined with chemotherapy.The change of Karnofsky performance status (KPS),appetite,body weight toxicum reaction and the whole body change of two groups were observed.Results Of 42 cases,20 cases (76.9％) improved on KPS in MPA combined with DCF group and 4 cases (25.0％) improved in DCF group,the difference between the two groups were statistically significant (P＜0.05) ; 21 cases (80.8％) had an increase on appetite and 19 cases (73.1％) had an increase on weight in MPA combined with DCF group,while the numbers in DCF group were 3 cases (18.8％) and 2 cases (12.5％) respectively,the difference between the two groups were statistically significant (P ＜ 0.05) ; 5 cases (19.2％) had grade Ⅱ or more gastrointestinal reaction in MPA combined with DCF group and 11 cases (68.8％)in DCF group,6 cases (23.1％) had grade Ⅱ] or more leucopenia in MPA combined with DCF group and 10 cases (62.5) in DCF group,the difference between the two groups were statistically significant (P ＜0.05).Conclusion MPA combined with DCF regimen chemotherapy can reduce gastrointestinal side effects and hematologic toxicities,increase appetite and improve life quality in patients with AGC.
Keywords：Medroxyprogesterone acetateDCF regimenAdvanced gastric cancerQuality of life
Publication Date：2013-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1259-1261 )