Association of non-alcoholic fatty liver disease with metabolic syndrome and its components
BAI Yu-rong
WANG Xi-ran
LI Xue
GE Ai-qing
WANG Zeng-wu
Abstract：Objective To explore the association of non-alcoholic fatty liver disease (NAFLD) with metabolic syndrome(MS) and its components in male.Methods A cross-sectional study on 1902 subjects who were divided into NAFLD group(n =778) and control group(n =1124) by the diagnosis standants of NAFLD.Blood pressure,body mass index(BMI),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholestrol(LDL-C),high density lipoprotein cholestrol (HDL-C),fasting and postprandial plasma glucose (FPG,2 h lPG) as well as blood uric acid(UA) were measured.Results The prevalence of NAFLD in male group was 40.9％.BMI,the presence of hypertension,TG,FPG,2 h PG,UA in male group were significantly higher in NAFLD group than in control group[(25.6 ±2.1)kg/m2 vs (23.7 ±5.6) kg/m2,33.8％ (263/778) vs 21.3％ (239/1124),(2.2 ± 1.4) mmol/L vs (1.4 ± 0.8) mmol/L,(8.2 ± 2.5) nnol/L vs (7.2 ± 1.7) mmol/L,(2.8 ± 0.7) mmol/L vs (2.7 ± 0.7) mmol/L,(425 ± 85) p mol/L vs (336 ± 100) μmol/L,P ＜ 0.01].HDL-C was lower in NAFLD group [(1.27 ± 0.28) mmol/L vs (1.44 ± 0.34) rmtol/L,P ＜ 0.01].Logistic regression analysis showed that the level of TG,HDL-C,2 h PG,UA,BMI and the presence of hypertension[odds ratios(95％ CI)were 1.6559(1.253-2.026),0.303 (0.1526-0.603),1.205 (1.100-1.320),1.003 (1.001-1.005),1.160 (1.069-1.259),1.69 (1.084-2.634) respectively; all P ＜ 0.05] were independent risk factors of NAFLD group; Compared with the control group more than two numbers of MS components were increased in NAFLD group.The prevalence of MS in male group was higher than in control group (41.7 ％ vs 13.7 ％,P ＜ 0.05).The relative risk (RR =4.48,95 ％ CI 3.0786-6.5281) for NAFLD group significantly increased in patients with MS in male group.Conclusions In male groups NAFLD is closely related with cluster metabolic disorders.The level of TG,HlDL-C,2 h PG,BMI and the presence of hypertension are independent risk factors of NAFLD in male group.The RR for NAFLD significantly increase in patients with MS in male group.
Keywords：Metabolic syndromeNon-alcoholic fatty liver diseaseMale
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1251-1253 )