Alpha-lipoic acid oxidative stress levels in patients with early diabetic nephropathy
QIU Chun-juan
L(U) Xiao-feng
ZHAO Jing
Abstract：Objective To observe alpha-lipoic acid(ALA) oxidative stress levels in patients with early diabetic nephropathy and the influence of the renal protective effect.Methods Eighty early diabetic nephropathy patients were randomly divided into experimental group and control group with 40 cases in each group.In addition,30 healthy people were as a normal group.The control group was given elementary treatment; the experimental group was additionally given ALA 0.6 g by inrtavenous drip infusion once a day.Both treatments lasted for 3 weeks.The blood level of malondialdehyde (MDA),advanced oxidation protein products (AOPPs),super oxide dismutase (SOD) and 24 h urinary albumin excretion rate (UAER) were compared before and after treatment.Results The blood level of MDA [(5.8 ± 2.1),(5.6 ± 2.3) μmol/L vs (3.8 ± 0.9) μmol/L],AOPPs [(69.4 ± 10.9),(69.2 ± 11.1) μmol/L vs (22.6 ± 2.9) μmol/L],24 h UAER[(274 ± 33),(270 ± 46) mg/24 h vs (12 ± 4) mg/24 h]were significantly increased and the level of SOD [(47 ±4),(47 ±4) U/ml vs (74 ±4) U/ml]was obviously reduced (P ＜ 0.05) in both groups compared with normal control group before treatment.There were no sigificant differences in MDA,AOPPs,SOD,24 h UAER in the control group(P ＞ 0.05),but in experimental group MDA[(2.7 ±1.9) μmol/L vs (5.6 ±2.3)μmol/L],AOPPs[(61.7±12.6)μmol/L vs (69.2 ±11.1)μ mol/L],24 h UAER[(183 ±42) mg/24 h vs (270 ±46) mg/24 h] were significantly decreased and SOD[(52 ±4) U/ml vs (47 ±4) U/ml] was significantly increased(P ＜ 0.05) compared with before treatment.Conclusions Oxidative stress in diabetic nephropathy plays an important role in the development.ALA can reduce the level of oxidative stress in diabetes and slow the progress of diabetic nephropathy.
Keywords：Alpha-lipoic acidDiabetic nephropathyOxidative stress
Publication Date：2013-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1246-1248 )