Influence of genetic factors on adolescent blood pressure

HONG Bin; SU Yan-ling; XIAO Lei; ZHANG Zheng

doi:10.3760/cma.j.issn.1673-4777.2013.09.007

Abstract：Objective To analyze the influence of genetic factors on adolescent blood pressure.Methods A total of 4175 schoolchildren aged 11-17 years in four schools in Shanghai were assessed in May 2010.All students were visited at school by trained nurses or physicians who administered a questionnaire and carried out anthropometric measurements.Anthropometric measurements included height,weight,heart rate and blood pressure, Repeat measurements were obtained in students with elevated blood pressure in one month.The pre-hypertension/ hypertension was defined on the basis of the 2004 National High Blood Pressure Education Program Working Group definitions.The overweight and obesity was defined using cutoff points recommended by Working Group of Obesity,China (WGOC).Results Participants were 15.0 ± 1.9 years old,with 52.3％ (2183 people) being girls and 47.7％ (1992 people) boys.Blood pressure distribution was 72.5％ (76.3％ for girls and 68.3％ for boys) normal,18.0％ (14.2％ for girls and 22.1％ for boys) pre-hypertension,8.3％ (344 people)stage 1 hypertension [8.2％ (179 people) for girls and 8.3％ (165 people) for boys] and 1.3％ (54 people)stage 2 hypertension [1.3％ (28 people)for girls and 1.3％ (26 people) for boys].A prevalence of overweight and obesity were 6.7％ (147 people) and 3.0％ (66 people)for girls; and 13.7％ (271 people) and 6.3％ (125 people)for boys.Father and/or mother with hypertension accounted for 13％ (541 people),12.6％ (251 people)for men,13.3％ (290 people) for female.The hypertension heritability had no significant difference between groups.Conclusion Genetic factors have no significant influence on adolescents hypertension; overweight and obesity may be associated with increased blood pressure level.