Predictors of left ventricular diastolic dysfunction factor research in atrial fibrillation patients
Abstract：Objective To find the predictors of left ventricular diastolic dysfunction (LVDD) in atrial fibrillation(AF) patients and assess the effect of catheter ablation on LVDD.Methods A retrospective study of patients (enrolled from November 2011 to June 2012) underwent ablation for paroxysmal AF.Two groups were compared:64 patients with isolated LVDD; and 57 patients with normal left ventricular function.Results Age,hypertension,left atrial(LA) size,A peak,E/e' ratio were higher in LVDD group than in control group [age:(62 ±9)years vs (66 ±5)years,hypertension:43.9％ (25/57) vs 68.8％ (44/64),LA size:(39 ±4) mm vs (41 ±4)mm,A:(59 ±20)cm/s vs (89 ± 19)cm/s,E/e':(8.3 ±2.5)vs (12.0 ±3.7),P＜0.05].E/A ratio was higher in control group [(1.47 ± 0.42) vs (0.85 ± 0.26),P ＜ 0.05].In multivariable regression analysis,age (OR =1.098,95％ CI:1.034-1.165,P =0.002) and LA size (OR =1.128,95％ CI:1.018-1.249,P =0.022) were associated with LVDD.The primary end point was achieved in 79.7％ (51/64) of patients with LVDD,and 82.5 ％ (47/57) in normal ones (P ＜ 0.05).In LVDD group,at least 1 grade improvement in diastolic dysfunction demonstrated in 25％ (16/64) of patients.The procedure time,ablation time,X-ray time and cardiac tamponade rate were of no statistics significant difference in the two groups (P ＞ 0.05).Conclusion LVDD occurs frequently in paroxysmal AF; LVDD is associated with advancing age and LA size; catheter ablation of AF in LVDD patients is effective and safe.
Keywords：Atrial fibrillationDiastolic dysfunctionCatheter ablation
Publication Date：2013-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1201-1203 )