Effects of tirofiban on interleukin and C reactive protein of patients treated with percutaneous coronary intervention
WANG Juan
LIU Yu
JIN Ping
Abstract：Objective To study the effects of tirofiban on interleukin(IL) and C reactive protein (CRP) in patients treated with percutaneous coronary intervention (PCI).Methods All 78 patients with PCI were randomly divided into the observation group (n =39) and control group (n =39).The patients in observation group were treated with tirofiban besides conventional therapy; the patients in control group were treated only with conventional therapy.Plasma levels of IL-6,IL-8,IL-10 and CRP were measured and compared before treatment and 24,72 h after treatment.Results The total effective rate in observation group was higher than that in control group[97.4％ (38/39) vs 89.7％ (35/39),P ＜ 0.05].After treatment for 24,72 h,the plasma levels of CRP,IL-6,IL-8 and IL-10 were lower than those before treatment in observation group and control group[control group:(10.4 ± 3.1),(7.6 ±2.9)mg/L vs (13.5 ±3.7)mg/L,(55 ±4),(40 ±4)mg/L vs (70 ±5)mg/L,(67 ±5),(48 ±3)mg/L vs (90 ± 7) mg/L,(8.8 ± 1.3),(8.0 ± 1.3) mg/L vs (9.8 ± 1.5) mg/L; observation group:(7.3 ± 2.8),(4.7 ±2.3)mg/L vs(13.5 ±3.7)mg/L,(42 ±4),(29±3)mg/L vs (69 ±5)mg/L,(55 ±5),(40 ±3)mg/L vs (90 ± 7) mg/L,(7.6 ± 1.3),(6.8 ± 1.2) mg/L vs (9.9 ± 1.5) mg/L],and the plasma levels of CRP,IL-6,IL-8 and IL-10 in observation group were lower than those in control group,and the difference was statistically significant (P ＜ 0.05).Conclusion Tirofiban can significandy reduce the levels of interleukin and CRP levels of patients with PCI.
Keywords：TirofibanPercutaneous coronary interventionInterleukinC reactive protein
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 1064-1065 )