Effects of improved-microinvasive hematoma evacuation on blood-brain barrier in patients with cerebral hemorrhage
WANG Gang
Abstract：Objective To explore the effects of improved-microinvasive hematoma evacuation on bloodbrain barrier (BBB) in patients with cerebral hemorrhage.Methods Valid patients with cerebral hemorrhage were divided into microinvasive hematoma evacuation group,small bone flap craniotomy group and conventional group.The patients in conventional group received the routine treatment,while small bone flap craniotomy group received the same treatment together with small bone flap craniotomy and microinvasive hematoma evacuation group also received the same treatment together with improved-microinvasive hematoma evacuation.The BBB index and myelin basic protein (MBP) were measured and analyzed before and after treatment respectively.Results There were no significant differences in BBB index and MBP among three groups before treatment.However,the BBB index and MBP in microinvasive hematoma evacuation group were significantly lower than those in small bone flap craniotomy group and conventional group after 3 days and 7 days treatment[after 3 days treatment,BBB index of microinvasive hematoma evacuation group,small bone flap craniotomy group and conventional group were 0.0095 ± 0.0008,0.0125 ± 0.0011,0.0129 ± 0.0009,MBP were (8.3 ± 1.3),(11.3 ± 1.4),(12.0 ± 1.6) μg/L; after 7 days treatment,BBB index of microinvasive hematoma evacuation group,small bone flap craniotomy group and conventional group were 0.0066 ± 0.0008,0.0098 ± 0.0007,0.0103 ± 0.0011,MBP were (2.2 ± 0.7),(5.2 ± 0.7),(5.4 ± 0.6) μg/L,P ＜ 0.05].Conclusion Improved-Microinvasive hematoma evacuation can reduce the lesion of cytotoxicity to BBB after cerebral hemorrhage.
Keywords：Cerebral hemorrhageMyelin basic proteinImproved-microinvasive hematoma evacuation
Publication Date：2013-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 924-926 )