Change and significance of serum tumor necrosis factor α, leptin and soluble vascular cell adhesion molecule-1 in blood serum in hypertensive patients complicated with diabetes mellitus
SU Jian-li
Abstract：Objective To investigate the change of serum tumor necrosis factor α(TNF-α),leptin,soluble vascular cell adhesion molecule-1 (sVCAM-1) in blood serum for essential hypertensive patients and essential hypertensive patients complicated with diabetes mellitus.Methods Seventy-five patients were divided into essential hypertension group (group B,34 cases) and essential hypertension combined with diabetes mellitus group(group C,41 cases).Thirty healthy people were chosen as normal control group.A double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was developed to test the level of TNF-α,leptin and sVCAM-1 in blood serum.Automatic blood biochemical analyzer and chemiluminescence were used respectively to detect the contents of fasting serum glucose (FPG) and fasting serum insulin (FINS) of the subjects.Insulin resistance index is estimated by homeostasis model assessment.Results ①The levels of TNF-α,leptin,sVCAM-1 and HOMA insulin resistance index (HOMA-IR) in group B and C were significantly higher than those in group A[TNF-α:(29.7 ±2.6),(32.9 ±3.8) μg/L vs (26.1 ± 2.7) μg/L; leptin:(5.9 ± 1.2),(12.8 ± 2.6) μg/L vs (3.2 ± 0.7) μg/L,sVCAM-1:(841 ±117),(947 ± 113) μg/L vs(678 ±87) μg/L,HOMA-IR:3.5 ±0.6,5.7 ±1.1 vs 1.3 ±0.5] (all P＜0.01),the indexes between group B and group C were significantly different as well(all P＜0.01).②In group B and C,the levels of TNF-α,leptin,sVCAM-1 were positively correlated with HOMA-IR (r =0.373,r =0.365,r=0.375,allP ＜0.05;r=0.518,r =0.469,r =0.674,allP ＜0.05).Conclusions ①TNF-α,leptin,sVCAM-1 are risk factors for hypertension and hypertension complicated with diabetes mellitus.②These indexes are also significantly associated with insulin resistance.
Keywords：HypertensionTumor necrosis factor αLeptinSoluble vascular cell adhesion molecule 1
Publication Date：2013-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 913-914 )