Effect of irbesartan and hydrochlorothiazide tablets on blood pressure and blood pressure variability of patients with essential hypertension
CONG Xiao-rong
QIN Jing-mei
SHI Xiao-ling
Abstract：Objective To observe the effects of irbesartan and hydrochlorothiazide tablets on blood pressure and blood pressure variability(BPV) of patients with essential hypertension.Methods Sixty patients with essential hypertension were treated with irbesartan and hydrochlorothiazide tablets 150 mg/d,the changes of 24 hours average blood pressure and BPV were compared prior to and after 8 weeks of treatment.Results The 24 hSBP,dSBP,dDBP、nSBP reduced obviously after treatment[(122 ±8)mm Hg (1 mm Hg=0.133 kPa) vs (151 ±24)mm Hg,(127 ±18)mm Hg vs (156 ± 19)mm Hg,(86 ±8)mm Hg vs (90 ±9)mm Hg,(118 ±9)mm Hg vs (127 ±8)mm Hg;all P ＜ 0.01].There was statistically significant difference in 24 hSBPSD,dSBPSD,dDBPSD,nSBPSD between pre and post treatment[(11.2 ±2.3)mm Hg vs (14.7 ±3.1)mm Hg,(15.1 ±8.5)mm Hg vs (18.3 ±7.0)mm Hg,(9.2 ±3.2)mm Hg vs (10.4 ±2.5)mm Hg; (13.7 ±7.7)mm Hg vs (16.6 ±7.3)mm Hg; P＜0.05 or P ＜ 0.01].Conclusion Irbesartan and hydroch-lorothiazide tablets can not only reduce hypertension,but also comtrol BPV and improve prognosis.
Keywords：Irbesartan and hydrochlorothiazide tabletsEssential hypertensionBlood pressure variability
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 911-912 )