Effect of C-reactive protein on clinical outcome after off-pump coronary artery bypass surgery
HUANG Xin-sheng
GU Cheng-xiong
WEI Hua
YANG Jun-feng
FANG Ying
LIU Rui
ZHOU Qi-wen
Abstract：Objective To investigate the relationship between serum levels of C-reactive protein(CRP) and cardiovascular events in patients with coronary heart disease after off-pump coronary artery bypass grafting.Methods From January 2002 to January 2007,we investigated 734 patients who underwent off-pump coronary artery bypass surgery.Preprocedural serum levels of CRP were measured in patients.According to the level of CRP,the patients were divided into two groups:CRP ≥3.0 mg/L-group (386 cases) and CRP ＜ 3.0 mg/L group (348 cases).The cardiovascular events (angina pectoris,myocardial infarction and death) was carefully observed and recorded after the procedures.Results The incidence of early outcome was not significant between CRP ≥ 3.0 mg/L group and CRP ＜ 3.0 mg/L group at postoperative 30 days (4.9％ vs 4.3％,P ＞ 0.05).Follow-up period was mean (5.2 ± 1.8) years.The frequency of cardiovascular events was significantly higher in CRP≥3.0 mg/L group than that in CRP＜3.0 mg/L group (22.0％ vs 12.2％,P ＜0.05).Multivariate analysis showed that preoperative CRP≥ 3.0 mg/L did not seem to be an useful marker in predicting outcome after postoperative 30 days,But it was an independent predictor of late cardiovascular events.COX proportional hazards models showed that CRP≥3.0 mg/L was an independent predictor of late cardiovascular events,followed by left ventricular ejection fraction ＜ 45％.Among operative survivors,patients in CRP ＜ 3.0 mg/L group had significantly higher 5-year overall survival rate than those in CRP ≥ 3.0 mg/L group [(94.0 ± 0.8) ％ vs (90.0 ± 1.2) ％,P ＜ 0.05],CRP ≥ 3.0 mg/L combined with left ventricular ejection fraction ＜ 45％ were associated with significantly decreased overall survival after procedure (88.0 ± 0.4) ％.Conclusions Serum levels of CRP may be a predictive of cardiovascular events in patients with coronary heart disease after off-pump coronary artery bypass grafting.It indicates that long-term clinical outcomes are related to the enhanced inflammatory response of blood vessel.
Keywords：Coronary heart diseaseC-reactive proteinCoronary artery bypass surgery
Publication Date：2013-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 900-902 )