Relationship between matrix metalloproteinase 2, 9 in plasmas of patients with ischemic heart disease and cardiac remodeling
Abstract：Objective To investigate the relationship between the activities of matrix metalloproteinase 2 (MMP-2),MMP-9 respectively in the plasmas of patients with ischemic heart disease (IHD) and left ventricular mass index (LVMI).Methods A case-control study with 254 IHD patients (observation group)and 214 control subjects (control group) frequency-matched by age and sex were conducted.The 254 patients with IHD were divided into cardiac remodeling group(128 cases) and non-remodeling group(126 cases) according to the levels of LVMI.The activity levels of plasma MMP-2 and MMP-9 were assayed by zymography.Results The activity of MMP-2 in cardiac remodeling group were significantly higher than those in control group and non-remodeling group [MMP-2:(13.0±2.9)m2/(g·L-1)vs(8.9±2.3),(10.9±2.9)m2/(g·L-1);MMP-9:(2.6±1.0)m2/(g· L-1) vs (1.4 ±0.4),(2.1 ±0.7)m2/(g · L-1),all P ＜0.05] ; the activity of MMP-9 and MMP-2 both in non-remodeling group of IHD patients were significantly higher than those in control group (P ＜ 0.05).The activity of the enzymes was correlated with cardiac remodeling (LVMI) (P＜0.05).Conclusion MMP-2 and MMP-9 in the plasma may have a role in the progression and/or acceleration of the left ventricular remodeling in heart failure and they may play important roles in the progression and/or acceleration of cardiac remodeling.
Keywords：Heart failureMatrix metalloproteinaseZymography analysisCardiac remodeling
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 597-599 )