Effects of statins on criminals endovascular plaques of patients with coronary artery disease: a five crossover study
YOU Qiong
WU Keng
LI Teng
YE Shao-qiang
MO Hai-liang
HUANG Rui-na
Abstract：Objective To evaluate the effects ofpravastatin,simvastatin,atorvastatin,lovastatin,fluvastatin on criminals endovascular plaques of patients with coronary artery disease (CHD).Methods Thirty-two CHD patients were randomly assigned to anyone of 5 medications sequences,respectively acceped pravastatin,simvastatin,atorvastatin,lovastatin,fluvastatin for 6 months,criminals endovascular endovascular plaques were quantitative analyzed by intravascular ultrasound (IVUS) technology during each drug treatment cycle.Results Plaque load change percentage reduced respectively,and the difference between atorvastatin and fluvastatin,lovastatin,simvastatin,pravastatin was statistical significant [(0.84 ± 0.05) ％ vs (0.44 ± 0.22) ％,(0.52 ± 0.03) ％,(0.39 ±0.07) ％,(0.56 ± 0.05) ％,P ＜ 0.01].Accordingly,incidence of angina of patients after treatment with atorvastatin administration reduced from (17.5 ± 1.5)times/week to (4.1 ± 0.4)times/week and was significantly more than other administration drugs [fluvastatin,lovastatin,simvastatin,pravastatin group was (10.7 ± 1.1),(10.4 ±1.1),(9.1 ± 0.3),(10.0 ± 1.2) times/week,respectively,P ＜ 0.01].Conclusion Standard doses of atorvastatin(20 mg daily) can more effectively stabilize criminals endovascular plaques than pravastatin,simvastatin,lovastatin,fluvastatin in patients with angina,thus it can effectively reduce the incidence of angina.
Keywords：Intravascular ultrasoundCoronary artery diseasePravastatinSimvastatinAtorvastatinLovastatinFluvastatin
Publication Date：2013-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 583-585 )