Correlation between serum homocysteine level and coronary lesion severity in coronary artery disease patients
SONG Yan-dong
ZHANG Jing-mei
WANG Su
TAO Ying
LI Zhi-zhong
Abstract：Objective To evaluate the correlation between serum homocysteine (Hcy) level and coronary lesion severity in coronary artery disease(CAD) patients.Methods A total of 512 patients receiving coronary angiography from January 2012 to December 2012 were retrospectively analyzed.According to SYNTAX score,CAD patients were divided into three groups:low-risk group (172 cases),middle-risk group (195 cases) and high risk group(145 cases).One hundred and eighty cases of normal coronary angiography over the same period were seemed as normal group.Fasting serum Hcy levels,fasting blood lipids including total cholesterol (TC),triglycerides (TG),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were determined.Results ①TC,LDL-C and Hcy were significantly higher in SYNTAX score high-risk group and middle-risk group compared with normal group.There was no statistically significant difference between the normal group and the low-risk group [TC,LDL-C and Hcy in middle-risk group were:(6.1 ± 0.7) mmol/L,(3.7 ± 1.0) mmol/L and (16.4 ± 2.0) μmol/L; In high-risk group were (7.2 ± 0.9) mmol/L,(4.2 ± 1.1) mmol/L and (19.5 ±1.8) μmol/L; In normal group were (4.5 ± 0.5) mmol/L,(2.9 ± 0.7) mmol/L and (10.8 ± 0.4) μmol/L,P ＜0.05].②272 cases had normal Hcy in 512 CAD patients.TC,TG,HDL-C,LDL-C and SYNTAX of them were (5.1 ±1.1)mmol/L,(1.4 ± 1.1)mmol/L,(1.2 ±0.3)mmoL/L,(3.5 ±0.9) mmol/L and (19 ± 10)scores; in high Hcy group,TC,TG,HDL-C,LDL-C and SYNTAX were (5.1 ± 1.2) mmol/L,(1.4 ± 1.6) mmol/L,(1.2 ± 0.3) mmol/L,(3.5 ± 1.0) mmol/L and (26 ± 11) scores.The SYNTAX score was significantly higher in high Hcy group than in normal group (P ＜ 0.05).③Multivariate Logistic regression analysis indicated that serum Hcy,TC,LDL-C were associated with coronary lesion severity(Hcy:r =0.24,TC:r =0.32,LDL-C:r =0.26,all P ＜ 0.05).Conclusions Serum Hcy is the risk factor of coronary lesion severity.With the increased Hcy level,the increase in the degree of coronary artery lesions,represent a greater cardiovascular risk.
Keywords：CysteineCoronary artery diseaseAngioplasty,balloon,coronarySYNTAX score
Publication Date：2013-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 580-582 )