Clinical analysis of 150 cases of enteric-coated aspirin induced upper gastrointestinal bleeding
LIU Ying
LI Ya-jun
Abstract：Objective To analyze the clinical features,risk factors,and prognosis of gastrointestinal bleeding associated with small doses of aspirin.Methods The clinical data of 150 patients with non-variceal upper gastrointestinal bleeding hospitalized in Beijing anzhen hospital from January 2011 to October 2012 were retrospectively analyzed.All 150 patients were divided into aspirin group including 71 patients and non-aspirin group including 79 patients.The clinical features,risk factors,and prognosis of two group were analyzed and compared.Results The age of upper gastrointestinal bleeding in aspirin group [(66 ± 12) old years] was higher than that in non-aspirin group [(56 ± 16) old years],and there was significant difference (P ＜0.05).The proportion of the occurrence of acute gastric mucosal lesions and helicobacter pylori infection in aspirin group were higher than the proportion of that in non-aspirin group [18.3 ％ (13/71)vs 3.8 ％ (3/79),26.8 ％ (19/71)vs 12.7 ％ (10/79)],and there were significant differences (all P ＜ 0.05).The hemoglobin in two groups were not significantly different [(83 ± 22) g/L vs (90 ± 25) g/L,P ＞ 0.05].The time of bleeding and hospitalization in aspirin group was significantly longer than those in non-aspirin group [(2.4 ± 0.9) d vs (1.7 ± 1.3) d,(13 ± 4) d vs (10 ± 4) d],which was significant difference (P ＜ 0.05).The patients took aspirin less than one months had less hemoglobin,took longer time of bleeding,stayed longer in hospital than the patients took aspirin more than one months in aspirin group [(55 ±20)g/L vs (86 ±20)g/L,(3.8 ±1.7)d vs (2.2 ±0.6)d,(17.3 ±1.8)d vs (12.3 ±3.6)d],and there were significant differences (all P ＜ 0.01).Conclusions Low-dose aspirin can increase the risk of gastrointestinal bleeding and gastric mucosal injury is common.The prognosis is poor because of large amount of bleeding.The patients at high risk of gastrointestinal bleeding should assess the risk of bleeding frequently.The treatment the helicobacter pylori and using anti-ulcer drugs before taking oral aspirin medication can reduce the risk of bleeding.
Keywords：Enteric-coated aspirinUpper gastrointestinal bleedingRelated factor
Publication Date：2013-04-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 498-500 )