Clinical effect of Shenxiong glucose injection for patients with membranous Nephropathy

SHENG Jie; ZHAO Jiu-yang

doi:10.3760/cma.j.issn.1673-4777.2013.04.022

Abstract：Objective To observe the clinical effect and the influence of hemorheology of Shenxiong glucose injection for patients with membranous nephropathy.Methods Forty inpatients with membranous nephropathy were chosen and divided to the Shenxiong group and conventional therapy group (20 cases each group).All patients received conventional therapy.The Shenxiong group were given Shenxiong glucose injection by intravenous infusions (200 ml/d for 14 days).Twenty-four hours urinary protein excretion,blood lipids,fibrinogen (Fib),hematocrit (HCT) measurement were measured before and after treatment,and the efficacy of the two groups were compared.Results Urinary protein decreased significantly after treatment in the Shenxiong group and the conventional therapy group (P ＜ 0.05),but the difference was not statistically significant (P ＞ 0.05).Triglyceride (TG),total cholesterol (TC),low-density lipoprotein-cholesterol (LDL-C),HCT and Fib in Shenxiong group after treatment decreased significantly [(7.3 ± 1.3) mmol/L vs (8.1 ± 1.3) mmol/L,(2.1 ± 0.5) mmol/L vs (2.5 ± 0.4) mmol/L,(2.2 ±0.7)mmol/L vs (3.1 ±0.8)mmol/L,(4.6 ±0.7)g/L vs (5.9 ±0.8)g/L,(38 ±3)％ vs (45 ±5)％](P ＜ 0.05),whereas the indicators had little improvement in the conventional therapy group (P ＞ 0.05),and the difference between two groups was statistically significant (P ＜ 0.05).Three cases (15.0％) occurred deep venous thrombosis in conventional therapy group,while no such complications occurred in the Shenxiong group.The difference was statistically significant (P ＜ 0.05).Conclusion Shenxiong glucose injection can improve the microcirculation and decrease blood lipid and blood viscosity of patients with membranous nephropathy.It is safe and effective and suitable promotion.