Effects of vitamin D on cardiac hypertrophy in type 2 diabetes rats
FAN Ying
ZHANG Xiao-shan
LUO Song-hui
HUANG Chao
Abstract：Objective To investigate left ventricular hypertrophy in type 2 diabetes rats and to explore the effects of vitamin D on the rats.Methods Forty Wistar rats were injected intraperitoneally with STZ and 37 rats were induced as diabetes successfully.After 8 weeks fostered,19 rats were identified as diabetes with left ventricular hypertrophy by ultrasound examination.They were randomly treated with insulin and vitamin D as experimental group.Six healthy Wistar rats were used as control.Fasting blood glucose and insulin were measured weekly.Left ventricular mass index,myocardial collagen content,myocardial collagen volume fraction and vitamin D receptors were detected at 4 weeks later.Results Compared to the normal control group,insulin level decreased significantly (P ＜ 0.05) but the fasting blood glucose level,left ventricular mass index,myocardial collagen content,myocardial collagen volume fraction and expression of vitamin D receptors were increased significantly in experimental group (P ＜ 0.05).Compared to the model group,insulin level in insulin treated group and vitamin D treated group increased significantly (P ＜ 0.05),and the other index decreased significantly (P ＜ 0.05).Conclusion Vitamin D can reverse cardiac hypertrophy in diabetes rats and the mechanism may involve reducing blood glucose and stimulating insulin secretion,and (or) reversing myocardial hypertrophy via vitamin D receptors directly.
Keywords：Diabetestype 2Vitamin DCardiac hypertrophy
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 482-484 )