Effects of rosuvastatin on hyperlidemia and carotid artery plaques in patients with carotid atherosclerosis
ZHANG Xuan
YI Gui-yan
DING Gui-xiang
CHEN Nian
YAN Qing
Abstract：Objective To study the effects of rosuvastatin on serum lipid level and carotid arterial intimamedia thickness (IMT) and carotid plaque score in patients with carotid atherosclerosis.Methods Seventy-six patients diagnosed by color doppler ultrasound with carotid artery plaque were given rosuvastatin 10 mg/d.Lipid levels and IMT were measured and carotid plaque score was calculated before and 6 months after the treatment.Results Six months after the treatment,serum TC level was reduced significantly from (6.3 ± 0.8) mmol/L to(4.4 ± 0.7) mmol/L.TG level was reduced significantly from (2.8 ± 0.5) mmol/L to (1.8 ± 0.3) mmol/L.LDL-C level was reduced significantly from (4.4 ± 0.4)mmol/L to (2.4 ± 0.3)mmol/L.HDL-C level was elevated significantly from (0.86 ±0.31) mmol/L to (1.21 ±0.27) mmol/L(P ＜0.05).Six months later,IMT reduced significantly from (1.77 ±0,32) scores to (1.24 ±0.27) scores,and carotid plaque score reduced significantly from (5.0 ± 0.4) scores to (3.3 ± 0.3) scores (P ＜ 0.05).Conclusions ①Rosuvastatin can significantly reduce serum TC,LDL-C,TG levels and elevate HDL-C level in patients with carotid atherosclerosis.②Rosuvastatin can significantly reduce IMT and carotid plaque score,which can stabilize and regress plaque in carotid artery.
Keywords：AtherosclerosisCarotid stenosisRosuvastatin
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 436-437 )