Observation of low-dose gemcitabine combined with carboplation in the treatment of advanced non-small cell lung cancer
SUO Hong
NIAN Ying
HAO Lu
Abstract：Objective To investigate the effect and safety of combination of chemotherapy with gemcitabine and carboplatin in the treatment of advanced non-small cell lung cancer.Methods Thirty-five patients with advanced non-small cell lung cancer received gemcitabine 800-1000 mg/m2 in half an hour at day 1 and 8,and carboplatin 300 mg/m2 at day 1 for at least two cycles.The response and toxicity of chemotherapy were evaluated and survival rate was followed up.Results Valuable cases partial response was observed in 10 cases,no change was seen in 13 cases,progress disease was seen in 12 cases.Overall response rate was 28.6％ and median survival time was 11.5 months and 1 year survival rate was 34.3％ (12/35).The most common toxicities were:leucopenia,thrombocytopenia and anaemiaand fatigue.These toxicities were well-tolerated.Conclusion The regiment of low-dose gemcitabine combined with carboplation is active and well tolerated in treating elderly patients with advanced non-small cell lung cancer.
Keywords：Non-small cell lung cancerLow doseGemcitabineCarboplation
Publication Date：2013-03-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 330-331 )