Analysis of drug resistance and clinical drug use countermeasures of klebsiella pneumoniae from lower respiratory tract infection
Abstract：Objective To investigate the drug resistance of klebsiella pneumoniae in the lower respiratory tract infection to guide the rational use of antibiotics.Methods ATB-expression analyzer was used to identify the microbe.The drug susceptibility was tested with the K-B method and the Extended-spectrumβ-lactamases (ESBLs) producing strains detected by diffusion confirmed test.Results A total of 1528 strains of klebsiella pneumoniae were isolated from 177 specimens and 40.1％ of them(71 strains) produced ESBLs.Results showed that the drug susceptibility of ESBLs-producing klebsiella pneumoniae antimicrobial resistance in common multiple of imipenem (0.0％),meropenem(0.0％),amikacin(23.9％),piperacillin/tazobactam(29.5％) and cefoxitin(31.0％) respectively.The drug resistance rate of ESBLs producing klebsiella pneumoniae was higher than that in non-producing ESBLs.Conclusions Klebsiella pneumoniae possesses multi-drug resistance.The clinician should strengthen monitoring of it and rationally use the antibiotics according to the result of antimicrobial susceptibility test.It is important to control nosocomial infection using imipenem and meropenem.
Keywords：Lower respiratory tract infectionKlebsiella pneumoniaeBeta-lactamasesAntibiotic resistance
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 327-329 )