Effects of Gelanxinning soft capsules on endothelial function after percutaneous coronary intervention in non-ST-segment elevation acute coronary syndrome patients

doi:10.3760/cma.j.issn.1673-4777.2013.03.002

Abstract：Objective To investigate the effects of Gelanxinning soft capsules on endothelial function after percutaneous coronary intervention (PCI) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients.Methods One hundred NSTE-ACS patients who would recept PCI were randomly divided into control group (n =50) and observation group (n =50).Patients in the control group were given conventional treatment,while patients in the observation group were treated with 4 Gelanxinning soft capsules three times a day for one month besides conventional treatment.The lipid and NO levels in serum and endothelin-1 level in plasma of all patients were detected before PCI and 1 month after PCI.Endothelium-dependent flow-mediated dilation (FMD) in all patients were measured on the day of admission and one month after the day of onset of PCI.Results Compared with the lipid level before PCI,the levels of lipid in both groups were lower one month after PCI (P ＜ 0.05).The levels of TG,TC and LDL levels in the observation group were much lower than in the control group(P ＜ 0.05).The level of endothelin-1 in both groups was lower[(66 ± 10) ng/L vs (74 ± 18) ng/L,(61 ± 15) ng/L vs (75 ± 24) ng/L,P ＜0.05] and NO was higher[(101 ± 8) μmo]/L vs (79 ±8)μmol/L,(131 ±7) μmol/L vs (79 ± 11) μmol/L,P＜0.05] after one month,and the observation group was more significantly improved than the control group (P ＜0.05).The level of FMD one month later in both groups was higher than that on the day of admission [(8.6 ±1.4) ％ vs (5.8 ± 2.2) ％,(9.0 ± 1.3) ％ vs (5.8 ± 2.1) ％ (P ＜ 0.05),while the level in the observation group was much higher than that in control group (P ＜ 0.05).Conclusion Gelanxinning soft capsules can further improve endothelial function and the lipid level after PCI in NSTE-ACS patients.