Assessment of different methods in patients with atrial septal defect concomitant with severe pulmonary hypertension
ZHAO Tie-fu
MA Han-ying
ZHOU Qi-wen
WANG Sheng-yu
Abstract：Objective To assess the effects of different therapies treating atrial septal defect (ASD) companied with severe pulmonary hypertension.Methods Sixty-one patients with ASD companied with severe pulmonary hypertension were enrolled into the study.According to the treatment strategy,all the patients were divided into three groups:group Ⅰ (21 cases,transthoracic non-cardiopulmonary bypass atrial septal defect occlusion) ; group Ⅱ (20 cases,valve repair with cardiopulmonary bypass) ; group Ⅲ (20 cases,traditional medical therapy).Group Ⅰ was treated with thoracotomy occlude; group Ⅱ had cardiopulmonary bypass valve application right to left a single valve with patch; group Ⅲ had simple drug treatment.Results During the previous 6 months follow-up,there was no difference in the six-minute walking distance among the three groups.At 12 month,the six-minute walking distance in group Ⅰ was respectively significantly higher than that in group Ⅲ[(358 ± 20)m vs(333 ± 21)m,P ＜0.05].At the 12th month,the six-minute walking distance in group Ⅰ was significantly higher than that in group Ⅲ [(358 ± 20)m vs(333 ± 21)m,P ＜ 0.05].At the 18th month,the six-minute walking distance in group Ⅰ,Ⅱ,Ⅲ was(376±21)m,(360±19)m,(330±19)m (P＜0.01 or P＜0.05).At the 24th month,the six-minute walking distance in group Ⅰ,Ⅱ,Ⅲ was (381 ± 17) m,(365 ± 20) m,(333 ± 19) m (P ＜ 0.01 or P ＜0.05).At the 30th month,the six-minute walking distance in group Ⅰ,Ⅱ,Ⅲ was (390 ± 20) m,(380 ± 21) m,(330 ± 18)m (P ＜ 0.01 or P ＜0.05).At the 36th month,the six-minute walking distance in group Ⅰ,Ⅱ,Ⅲ was (415 ± 18) m,(400 ± 19) m,(329 ± 18) m (P ＜ 0.01 or P ＜ 0.05).Conclusions For the patients with ASD companied with severe pulmonary hypertension,the treatment effect of surgical therapy is much better than traditional medical therapy.The six-minute walking test is a convenient method to effectively assess the prognosis of patients with severe pulmonary hypertension.
Keywords：Atrial septal defectPulmonary hypertensionSix-minute walking test
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 289-291 )