Expression of fragile histidine triad and caspase-3 in tissue of endometrial carcinoma
CHEN Rui-lian
ZHENG Xiu
LI Li-jun
Abstract：Objective To detect the expression of the fragile histidine triad(FHIT) and caspase-3 protein in endometrial adenocarcinoma (EC),endometrial atypical hyperplasia (EIN) and the normal endometrium.To explore the relation between FHIT and caspase-3 in the genesis and progression of endometrial carcinoma.Methods The expression of FHIT and caspase-3 protein in 60 cases of EC,30 cases of EIN and 30 cases of normal endometrial tissue were detected by streptavidin-peroxidase (SP) immunohistochemical staining.The clinicopathological characteristics of patients and the relevance of FHIT and caspase-3 were analyzed.Results The positive rates of FHIT in EC,EIN and normal endometrium were 53.3％ (32/60),63.3％ (19/30) and 100.0％(30/30),respectively.The positive rates of caspase-3 in EC and EIN and normal endometrium were 51.7％ (31/60),70.0％ (21/30),86.7％ (26/30),respectively.The positive rates of FHIT and caspase-3 in EC were significantly lower than those in normal endometrium,the difference was statistically significant (P ＜ 0.01).Thepositive expressions of FHIT and caspase-3 were all related to the organizational grade of EC (G1:x2 =9.312,G2-3:x2 =14.299,all P ＜ 0.01).The positive expressions of FHIT was associated with the surgical-pathologic staging of EC(Ⅰ-Ⅱ,Ⅲ-Ⅳ),myometrial invasion (≤1/2,＞ 1/2) and lymph node metastasis (negative,positive) (all P ＜ 0.05).Conclusions FHIT and caspase-3 may be associated with the occurrence of endometrial adenocarcinoma.The combined detection of FHIT and caspase-3 protein may become important indexes of early diagnosis and forecasting of EC.
Keywords：Endometrial neoplasmsFragile histidine triadCaspase-3
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 210-212 )