Levels of oxidative stress in patients with urothelial bladder carcinoma
L(U) Yi-song
MAO Hou-ping
ZHOU Hui-liang
GAO Rui
XUE Xue-yi
ZHENG Qing-shui
LIN Xi
CAO Lin-sheng
LUO Yi-qi
Abstract：Objective To assess the changes of oxidative stress in patients with bladder urothelial carcinoma.Methods All 159 patients (Ta + T1,117 ; ≥ T2,42) were bladder urothelial carcinoma and 120 healthy controls were chosen.Vitamins C and E,superoxide dismutase (SOD),glutathione peroxidase (GPx),malondialdehyde (MDA) and total antioxidant activity (AOA) were estimated.Results The serum levels of vitamins C and E,SOD,GPx and AOA were significantly lower [(0.023 ± 0.006)mg/L vs (0.057 ± 0.009)mg/L,(0.082 ± 0.021) mg/L vs (0.149 ± 0.012) mg/L,(31 ± 12) kU/L vs (201 ± 31) kU/L,(2136 ± 436) U/L vs (7674 ± 922) U/L,(0.90 ± 0.04) nmol/L vs (1.67 ± 0.29) nmol/L,all P ＜ 0.01] while serum MDA levels were significantly higher in patients than those in controls[(12.6 ±4.2) μ mol/L vs (3.1 ±0.9) μmol/L,P ＜0.01].There were significant differences between the patients with non-muscle invasive bladder tumors and muscle invasive tumors for vitamins C and E,SOD and GPx [(0.027 ± 0.014) mg/L vs (0.012 ± 0.005) mg/L,(0.095 ±0.019) mg/L vs (0.046 ± 0.007) mg/L,(37.12 ± 10.9) kU/L vs (14.9 ± 2.7) kU/L,(2422 ± 457) U/L vs(1339 ± 264) U/L,all P ＜ 0.01],except AOA (P ＞ 0.05).Conclusions The oxidative stress of bladder urothelial carcinoma in correlation with the severity of the disease,and it may be important factors in tumor development and growth.These findings suggest possible use of antioxidant supplementation as prophylactic agent for prevention and treatment of bladder cancer.
Keywords：Urinary bladder cancerOxidative stressVitaminsAntioxidants
Publication Date：2013-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 196-198 )