Clinical observation of sorafenib monotherapy in patients with advanced primary liver cancer
ZHOU Qin
ZHU Hai-peng
WU Ke-xiong
TANG Yan
HU Jun
Abstract：Objective To observe the efficacy and side effects of sorafenib monotherapy in patients with advanced primary liver cancer.Methods All 21 patients with advanced primary liver cancer were treated by sorafenib 400 mg twice daily,and the efficacy and side effects of sorafenib monotherapy were evaluated after sorafenib treatment for 6 weeks.Results Of 21 patients,4 patients achieved partial remission,10 patients achieved stable disease,and 7 patients achieved progression of disease; time to progress was 5.2 months,The main side effects:19 cases occurred hand-foot skin reaction,and grade one,two and three was in 10,8 and 1 case,respectively; diarrhea was in 6 cases,and all were grade one; 5 cases undertook nausea/vomiting,and all was grade one; skin rash was in 10 cases,and the grade one was 3 cases,grade two was 7 cases; 4 cases was baldness;lack of power,stomatitis and hypertension was in 1 case respectively,and all were grade one.Conclusion Sorafenib monotherapy in advanced primary liver cancer can control the growth of tumor.
Keywords：Live tumor,advance,primarySorafenibToxic reaction
Publication Date：2013-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 191-192 )