Fibrinogen level in patients with cerebral infarction caused by severe extracranial carotid stenosis

XIE Ling-ling; LIU Tian-cheng; LIU Xue-mei

doi:10.3760/cma.j.issn.1673-4777.2013.02.011

Abstract：Objective To test the level of fibrinogen in patients with acute cerebral infarction caused by severe extracranial carotid artery stenosis.Methods All 83 patients with acute cerebral infarction,35 patients with asymptomatic severe carotid artery stenosis and 50 healthy volunteers (as a control group) were selected,the fibrinogen levels were tested to find the relativity among them and analyze the relevance with cerebral infarction type,the degree of neurologic function defect and state of stroke.Results The fibrinogen levels of the cerebral infarction group were significantly higher than those in asymptomatic severe carotid artery stenosis group and control group [(309 ± 65) g/L vs (280 ± 18) g/L,(262 ± 25) g/L] (P ＜ 0.05) ; the fibrinogen levels of regional cerebral infarction were significantly higher than those of the control group [(421 ± 22) g/L vs (318 ± 63),(303 ± 66),(293 ± 54)g/L] (all P ＜ 0.05).Fibrinogen levels of unstable plaque group were significantly higher than that of the stable plaque group [(357 ±45)g/L vs (257 ±41)g/L] (P ＜0.05).The level of fibrinogen in severe nerve function defect group were obviously higher than those in light and moderate nerve function defect group [(412 ±27) g/L vs (255 ±27),(358 ±27)g/L],and the level of fibrinogen in good prognosis group was lower than that in bad prognosis group[(282 ±55)g/L vs (373 ± 38) g/L],and there were significant differences (all P ＜0.01).Conclusion The level of fibrinogen is closely related to severe carotid artery stenosis and cerebral infarction by severe carotid artery stenosis,which support specific infarction type and can indicate the severity and prognosis of the disease.