Effects of Shuganjieyu capsule in post-stroke depression and nervous function defect

WANG Shuai; SHI Xiao-jing; DUAN Hong-jun; ZHANG Chun-rong; YANG Wen-jun; ZHANG Yan-yan

doi:10.3760/cma.j.issn.1673-4777.2013.02.009

Abstract：Objective To explore the effects of Shuganjieyu capsule on post-stroke depression,nervous function defect and activities of daily living.Methods All 66 patients with post-stroke depression were randomly divided into two groups:observation group (routine treatment combined with Shuganjieyu capsule) and control group (routine treatment only).Hamilton rating scale for depression (HAMD),national institutes of health stroke scale (NIHSS) and Barthel index score were used for the two groups before treatment and after treatment.Results Compared to before treatment,the score of HAMD did not decrease in control group(P ＞ 0.05),and decreased in observation group after treatment for 3 and 4 weeks [(10.1 ± 2.1),(7.8 ± 2.0) scores vs (27.1 ± 8.1) scores,P ＜0.01] ; the score of NIHSS decreased obviously in observation group and control group after treatment for 3 and 4 weeks [observation group:(7.3 ± 1.7),(3.9 ± 1.7) scores vs (17.6 ± 2.9) scores; control group:(9.4 ±2.0),(6.2 ± 1.9) scores vs (17.9 ± 3.2) scores,P ＜ 0.05 or P ＜ 0.01] ; the score of Barthel index in observation group and control group increased significantly after treatment for 4 weeks [observation group:(74 ± 6) scores vs (27 ± 6) scores ; control group:(54 ± 7) scores vs (28 ± 7) scores,P ＜ 0.05,P ＜ 0.01].Compared to the control group,HAMD scores in observation group decreased after treatment for three and four weeks,and there were significant difference between two groups (P ＜ 0.05) ; the NIHSS in observation group were lower than those in control group,but there was no significant difference(P ＞ 0.05) ; the score of Barthel index increased in observation group after treatment for four weeks,and the difference was significant (P ＜ 0.05).Conclusion Shuganjieyu capsule is an ideal antidepressant which can improve post-stroke depression,the nervous function defect and activities of daily living.