Effect of target-controlled propofol on serum level of S100B protein in patients with severe head injury
HU Wei
WANG Jun
L(U) Hua-rong
WU Xing
CHEN Zhi-gong
Abstract：Objective To investigate the effect of target-controlled propofol on serum level of S100B protein in patients with severe head injury.Methods Forty patients with severe head injury were randomly divided into routine treatment group and propofo group with twenty cases in each group.All patients had the emergency craniotomy operation.The routine treatment group was only given routine therapy before and after operation,including sedation,dehydration,hemostatic,inflammatory,neurotrophy and supportive therapy; the propofol group was given the basis treatment plus the target-controlled propofol for at least three days after operation.The serum S100B levels were measured before operation,the 1 d,3 d,5 d,7 d after operation.Results The S100B levels in propofo group were significantly decreased in 1 d [(3.19 ±0.25)μg/L],3 d[(2.48 ±0.23)μg/L],5 d [(2.22 ± 0.27) μg/L] and 7 d [(2.00 ± 0.21) μg/L] after operation compared with routine treatment group [(3.23 ±0.20) μg/L,(2.89 ±0.28)μg/L,(2.55 ± 0.26) μg/L,(2.30±0.20)μg/L] (all P＜0.05).Conclusions Propofol of target controlled can effectively reduce the serum S100B levels in severe craniocerebral injury patients after the operation and protect neurocytes.
Keywords：Traumatic brain injuryPropofolTarget-controlled infusionS100B protein
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 47-48 )