Analysis of risk factors of delayed encephalopathy after acute carbon monoxide poisoning

WANG Wei-qiang; WANG Qin-yong; LI Li; LI Xiao-hong

doi:10.3760/cma.j.issn.1673-4777.2013.01.016

Abstract：Objective To explore the risk factors for delayed encephalopathy after acute carbon monoxide poisoning (DEACMP).Methods All 198 patients with DEACMP were enrolled as DEACMP group,and 130 patients without DEACMP after acute carbon monoxide poisoning (ACMP) were as ACMP group.The general conditions(including age,gender,body mass index,occupation),poisoning degree,coma duration,the time of treatment of hyperbaric oxygen,complications after ACMP and brain image of CT/MRI were analyzed.Results The rates of age ＞ 60 years,brainworkers,living alone in DEACMP group[65.2％ (129/198),24.7％ (49/198),48.5％(96/198)] were higher than those in ACMP group[50.0％ (65/130),13.8％ (18/130),19.2％ (25/130)].The severe poisoning patients were more in DEACMP group than in ACMP group [58.1％ (115/198) vs 9.2％(12/130),P ＜ 0.01].The patients accompanied with cardiovascular and cerebrovascular diseases (including insufficiency of brain blood supply,encephalatrophy,coronay heart disease and hypertension) or diabetes in DEACMP group were more than those in ACMP grup(P ＜0.05 or P ＜0.01).The rates of coma duration more than 24 h and the time of treatment of hyperbaric oxygen treatment for more than 4 h in DEACMP group were higher than those in ACMP group (P ＜ 0.05 or P ＜0.01).The patients accompanied with complications and brain injury in DEACMP group were more than those in ACMP group(P ＜ 0.05 or P ＜ 0.01).The multiple factor regression analysis explored 8 risk factors of DEACMP,including poisoning degree,coma time,brain materially injury,living alone,pulmonary infection,the time accepted treatment of hyperbaric oxygen,multiple organ dysfunctions and brainworkers.Conclusion There are versatile risk factors of DEACMP.