Clinical analysis of connective tissue diseases with interstitial lung disease

ZHANG Jia-lin; YE Bao-guo; CHEN Hong-pu

doi:10.3760/cma.j.issn.1673-4777.2013.01.013

Abstract：Objective To observe the diagnosis of connective tissue diseases with interstitial lung disease.Methods The clinical manifestations of respiratory,pulmonary function tests,lung imaging characteristics,the presence or absence of pulmonary hypertension,pulmonary function in 124 patients with interstitial lung disease associated with connective tissue disease were retrospective analyzed.Results Cough,expectoration,shortness of breath,chest stuffiness and choking were common respiratory symptoms.The fall of activity tolerance and dyspnea were serious respiratory symptoms.64 patients had pulmonary function test and all of them showed a decreasing diffusing capacity.Among them,26 only showed diffusing capacity reduction,32 restrictive ventilation defect with diffusing capacity reduction,4 mixed ventilation defect with diffusing capacity reduction and 2 obstructive ventilation defect with diffusing capacity reduction.22 patients had pulmonary artery high pressure.In image,the features of interstitial lung diseases displayed as follows:nodus,steak,patchy sign,grid,ground-glass opacities and bullae of lung.The features of interstitial lung diseases displayed as grid and fibrosis in 15 of 32 restrictive ventilation defect with diffusing capacity reduction.Conclusions The respiratory symptoms of c onnective tissue diseases with interstitial lung disease are various.Pulmonary function of connective tissue diseases with interstitial lung disease primarily displays a restrictive ventilation defect with diffusing capacity reduction.Connective tissue diseases complicated with interstitial lung disease and of pulmonary arterial hypertension easily occur in mixed connective tissue disease (MCTD),overlap connective tissue disease,systemic lupus erythematosus (SLE) and systemic sclerosis(SSc).In image,the features of interstitial lung diseases is various.Among them,grid and fibrosis are related to pulmonary function of restrictive ventilation defect with diffusing capacity reduction.