Effect of moderate hypothermia on tumor necrosis factor-alpha and interleukin-2 levels of patients after cardiopulmonary resuscitation
CHEN Wei
TENG Qing-ping
LU Hai-yan
WANG Shu-qin
Abstract：Objective To explore the influence of therapeutic hypothermia on tumor necrosis factor α (TNF-α)and interleukin 2 (IL-2) in peripheral blood in cardiopulnonary resuscitation of cardiac arrest patients.Methods Totally 30 patients of successful cardiopulmonary resuscitation from January 2008 to January 2011 were divided into the hypothermia therapy group(n =15) and the routine therapy group(n =15).The changes of TNF-α,IL-2 of the two groups were observed in each time period in hospital,serious complications and mortality rate were compared between two groups.Results TNF-α in the therapeutic hypothermia increased.There was no significant difference of TNF-α at 30 min and 2 hour between hypothermia therapy group and the routine therapy group.IL-2 in the hypothermia therapy group was lower than that in the routine therapy group from 6 hours to 72 hours [6 h:(28.67±5.54)ng/L vs (58.56 ±3.34)ng/L,12 h:(38.56 ± 2.67) ng/L vs (73.65 ±7.12)ng/L,24 h:(46.96±6.54)ng/L vs (93.45 ± 8.43) ng/L,72 h:(43.53 ±7.32)ng/L vs (73.21 ±6.65)ng/L,P ＜0.05].IL-2 in the hypothermia therapy group was low than that in the routine therapy group at 30 min,1 hour,2 hours,6 hours,12 hours,24 hours and 72 hours; but IL-2 in the hypothermia therapy group was low than that in the routine therapy group [30 min:(0.18 ± 0.03) ng/L vs (0.24 ± 0.04) ng/L,1 h:(0.22 ± 0.06) ng/L vs (0.33 ±0.05)ng/L,2 h:(0.30±0.04)ng/L vs (0.41 ±0.03) ng/L,6 h:(0.35 ± 0.05) ng/L vs (0.56 ±0.04) ng/L,12 h:(0.36 ±0.03)ng/L vs (0.60 ±0.06)ng/L,24 h:(0.44 ±0.03)ng/L vs (0.63 ±0.04) ng/L,72 h:(0.44±0.04)ng/L vs (0.69±0.01) ng/L,P＜0.05].The serious complications and mortality rate in the hypothermia therapy group were lower than those in the routine therapy group(P ＜0.05).Conclusions Moderate hypothermia can reduce TNF-α and IL-2,inhibit inflammatory responses and reduce serious complications and mortality rate.
Keywords：Heart arrestCardiopulmonary resuscitationMild hypothermia treatmentTumor necrosis factor-alphaInterleukin-2Mortality rate
Publication Date：2013-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 25-27 )