Analysis of continuous renal replacement therapy during post-operative period among patients with severe heart valve diseases
LIU Ruo-fan
SHI Yi
HUANG Chen
XU Jian-ping
Abstract：Objective To observe patients with severe heart valve diseases who had continuous renal replacement therapy(CRRT) after cardiopulmonary bypass.Methods Patients with severe heart valve diseases who underwent cardiac surgery between October 2010 and April 2012 were treated with CRRT due to renal dysfunction,cardiovascular dysfunction,severe electrolyte disturbance or infectious shock (n =32).CRRT was removed when the condition was stable.Creatinine level,blood urea nitrogen (BUN) level,aspartate aminotransferase level,oxygen partial pressure,central venous pressure (CVP)and urine output were compared before and after CRRT.Results The cardiopulmonary bypass time of the patients was 140.00(79.50,207.75) min; the aortic cross time was 98.00 (45.50,130.75) min ; the time until CRRT after admission to the ICU was 46.50 (21.25,110.00) h.After 52.50 (42.25,72.25) h of CRRT application,the renal function and heart function of the patients were improved.The urine output [0.77 (0.17,1.34) ml/(kg · h) vs 0.42 (0.29,0.61) ml/ (kg · h),P =0.007] and systolic pressure[(106±25)mm Hg(1 mm Hg =0.133 kPa) vs (97 ±24)mm Hg,P=0.014] increased obviously; central venous pressure [(9 ±4)cm H2O(1 cm H2O =0.098 kPa) vs (12 ±3)cm H2O,P =0.001],creatinine level[129.00(100.60,161.30)g/L vs 209.00(153.70,268.30)g/L,P ＜0.001],blood urea nitrogen level[12.70(6.93,17.33)g/L vs 15.20(10.10,28.90)g/L,P =0.017] and aspartate aminotransferase level [79.00(42.25,134.00) g/L vs 195.00(70.25,689.50) g/L,P =0.003] all decreased.Three patients died of heart failure ; one patient died of cardiac arrest ; one patient was sent to other hospital for further renal treatment ;the others discharged from hospital after completely cured.Conclusion The effective use of CRRT can help patients with severe heart valve diseases during the post-operative period.
Keywords：Heart valve diseaseValve replacementContinuous renal replacement therapy
Publication Date：2013-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 19-21 )