Impact of intensified statin therapy prior to percutaneous coronary intervention on high-sensitivity Creactive protein and von willebrand factor in patients with non-ST segment elevation acute coronary syndrome
WANG Fei
YANG Jie-ying
CHEN Shu-yan
Abstract：Objective To observe the impact of intensified statin therapy prior to percutaneous coronary intervention (PCI) on high-sensitivity C-reactive protein (hs-CRP) and von willebrand factor (vWF) in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS).Methods One hundred NSTE-ACS patients were enrolled and randomized into aggressive statin therapy or normal dose group.Both groups received standard medical therapy and the standard group received simvastatin 20 mg per day and the aggressive treatment group received atorvastatin 40 mg per day for 7 days prior to PCI.All patients received standard coronary angiography and PCI.Levels of hs-CRP and vWF were measured and compared on the procedural day and 24 hours after PCI.Results The level of hs-CRP was significantly reduced after aggressive statin treatment compared to normal dose (P ＜ 0.05).Increase of hs-CRP was observed in both groups after PCI,however the increase was more significant with normal dose (P ＜0.05).Increase of vWF level was significantly lower in the aggressive treatment group after PCI [(151 ± 54) μg/L vs (204 ± 125) μg/L,P ＜ 0.05].Conclusions Intensive statin therapy prior to PCI is effective in reducing hs-CRP and vWF levels in NSTE-ACS patients.
Keywords：Acute coronary syndromeAngioplastyballooncoronaryC-reactive proteinVon willebrand factorAntilipemic agents
Publication Date：2013-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 4-6 )