Study on clinical feature of sporadic Creutzfeldt-Jakob disease (2 cases report)
LIN Hao
YIN Shi-min
WANG Lei
Abstract：Objective To investigate the clinical feature,MRI,electroencephalography(EEG) and results of CSF of sporadic Creutzfeldt-Jakob disease.Methods The clinical feature,MRI,EEG and the detection of 14-3-3 protein were retrospectively analyzed.Results Both of two cases expressed the processing mental obstacles,case one was found abnormal mental activities before the processing mental obstacles.24 h-EEG showed typical periodic triphasic wave in both cases.Both cases were found abnormal hyperintense signal in cerebral cortex and basal ganglia on T2-weighted image and diffusion-weighted image.Detection of 14-3-3 protein in cerebrospinal fluid in both cases were positive.Conclusion For prospective patients with processing mental obstacle,abnormal mental activities accompanied by multi-system involvement,MRI,24 h-EEG and detection of 14-3-3 protein is helpful for early diagnosis of sporadic Creutzfeldt-Jakob disease in suspected cases.
Keywords：Creutzfeldt-Jakob diseasesporadicProtein 14-3-3Electroencephalogram
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)