Fluoroquinolone ketone drug in treatment of drug resistant tuberculosis: cost-effectiveness analysis
WANG Xiu-li
ZENG Shao-yi
LIANG Zhao-he
WANG Yuan-hong
Abstract：Objective To discuss and compare the economic effect and the optimal treatment regimen of 3 kinds of fluoroquinolone drug including ofloxacin,levofloxacin,moxifloxacin in treatment of drug resistant tuberculosis (MDR-TB).Methods All 108 cases of MDR-TB confirmed by speutum examination were randomly divided into 3 groups,The patients in three groups were given a certain amount of rifapentine isoniazid,pyrazinamide,salicylic acid,propylene ethionamide,streptomycin,during anti-tuberculosis scheme,oxygen fluorine ofloxacin,levofloxacin,moxifloxacin added,respectively.Cost-effectiveness analysis method was taken,and the cost and effectiveness were evaluated.Results After 15 months of treatment,in the sputum negative conversion rate,radiologic lesions absorption rates,levofloxacin and moxifloxacin had similar effects,and were superior to that of ofloxacin; adverse reaction and other indicators among three groups had no significant statistical difference.There was a statistically significant difference in the medical expenses among three groups.Conclusion Levofloxacin in treatment of drug resistant tuberculosis is the best therapeutic scheme.
Keywords：TuberculosisPulmonaryFluoroquinoloneCosts and effectiveness analysisMoxifloxacin
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)