Narrow band ultraviolet monotherapy for severe psoriasis
ZHAO Yi
GUAN Xin
WANG Bing
YANG Hai-zhen
Abstract：Objective To assess the efficacy and safety of narrow-band ultraviolet (NB-UVB) monotherapy for severe psoriasis.Methods Psoriasis patients were included in the study and assigned to mild-moderate group A [psoriasis area and severity index (PASI) ＜ 15] and severe group B (PASI ≥ 15).Assessment of efficacy was made on week 2,4,6,8,12 with PASI score.Adverse events were recorded at each visit.Statistical comparison was made regarding efficacy and safety.The primary endpoint analysis was made on week 8.Results Eighty-three patients were included in two groups.PASI reduction at week 8 was 68.2％ (60.0％,78.6％) and 77.5％ (51.0％,88.4％) in group A and B.PASI in group A was 45.5％/21.2％,and it was 56.0％/28.0％ in group B.The PASI reduction and PASI75 of group A [22.8％ (10.0％,46.3％) and 12.1％] were both significantly higher than those of group B [13.4％ (0.0％,27.1％),0％].Mild erythema and edema were the main adverse events.Conclusions NB-UVB monotherapy is effective for both mild-moderate and severe psoriasis.The overall response to treatment of severe psoriasis is no worse than that in mild-moderate patients.However the patients with mild-moderate psoriasis respond more quickly in the early stage of treatment.
Keywords：PsoriasisSevereNarrow band ultraviolet
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1595-1597 )