Auto-antibody in lung cancer and connective tissue diseases in eldely people
ZHANG Ying
TANG Hua-ping
LIU Shuang-mei
GONG Qiao-li
MAN Guo-yu
Abstract：Objective To understand the relationship of auto-antibody (include antinuclear antibodies and rheumatoid factor) between lung cancer and connective tissue diseases in eldly people.Methods Western blotting was used to identify the antinuclear antibodies (ANAs),and immunoturibidimetric assay were used to detected rheumatoid factor(RF).The ANAs and RF among 90 cases of lung cancer(diagnosed by pathology or cytology),50 cases of connective tissue diseases and 36 cases of health people were all observed.Results The positive rate of ANAs in lung cancer group[46.7 ％ (42/90)] was significantly different compared with healthy people group [8.3 ％(3/36)],so was it in connective tissue diseases compared with healthy people group; the significant difference of high positive rate of ANAs was present in people older than 60 years old compared with people younger than 60 years.There were no significant difference of ANAs between lung cancer and connective tissue diseases among patients older than 60 years.The positive rate of RF in connective tissue diseases group [78.0％ (39/50)] was significantly different compared with lung cancer [6.7％ (6/90)] and healthy people group(0).Conclusions The positive rate of RF in connective tissue disease is higher than that in lung cancer.ANAs can not be used to differentiate lung cancer from connective tissue diseases,especially in people older than 60 years.
Keywords：Lung cancerConnective tissue diseasesAntinuclear antibodiesRheumatoid factor
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1512-1514 )