Effects of folate on changes of 8-isoprostane F2α and 6-keto-prostaglandin F1α in patients with type 2 diabetes mellitus
JU Hai-bing
XU Xin-ming
SHU Zi-zheng
WANG Guang-lin
LI Li-feng
SONG Jie
SUN Xiaojuan
YU Jing
Abstract：Objective To explore the effects of folate on changes of 8-isoprostane F2α(8-IPF2α),6-keto-prostaglandin-F1α(6-K-PGF1α)and oxidative stress in patients with type 2 diabetes mellitus.Methods Ninetyeight patients with type 2 diabetes mellitus on oral hypoglycemic drugs were randomly divided into two groups ; 88 of 98 subjects completed the study.There were 46 participants(control group)who received a 3-month course of oral hypoglycemic drugs;the remaining 42 patients(experiment group)received oral hypoglycemic drugs and folate 15 mg daily.Serum Hcy,folate,8-IPF2α,6-K-PGF1α were measured at baseline and after treatment.Results There was no significant difference in clinical data and serum Hcy,folate,8-IPF2α,6-K-PGF1α between two groups before treatment.Compared with the control group,experiment group with folate showed a significant increase in serum folate [(13.3 ±2.6)pmol/L vs(11.5 ± 2.4)pmol/L,P ＜0.05]and 6-K-PGF1α [(84 ± 14)ng/L vs(70 ± 12) ng/L,P ＜ 0.05]and decreased in serum Hcy [(19.2 ± 2.3)μmol/L vs(11.1 ± 2.8)μmol/L,P ＜ 0.05]and 8-IPF2α[(21 ± 3)ng/L vs(35 ± 7)ng/L,P ＜ 0.01].Conclusion The administration of folate reduces oxidative stress in type 2 diabetes mellitus.
Keywords：Diabetestype 2Folate8-isoprostane F2α6-keto-prostaglandin F1αOxidative stress
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)