Clinical applicability of serum tumor markers(CK-2G2 and Cyfra21-1)for efficacy assessment of chemotherapy in patients with non-small-cell lung cancer
WU En-dong
SONG Li-hong
GOU Xiu-li
LIANG Zi-kun
YIN Yan-jun
SHI Guang-li
LUO Bao-jian
Abstract：Objective To investigate the clinical significance of cytokeratin 19-2G2(CK-2G2)and Cyfra21-1 for assessment of efficacy of chemotherapy in patients with non-small-cell lung cancer. Methods The serum levels of CK-2G2 and Cyfra21-1 were detected by Chemiluminescence(CLIA)in 124 patients with non-small-cell lung cancer before chemotherapy,after treatment for one period and after treatment for two periods.Results The levels of CK-2G2 and Cyfra21-1 in patients with adenocarcinoma after treatment for one period were significantly lower than those of patients before chemotherapy[0.77(0.03-55.85)U/L vs 1.86(0.02-55.60)U/L,1.88(0.15-18.65)μg/L vs 2.35(0.14-22.32)μg/L](P ＜ 0.05).The levels of CK-2G2 and Cyfra21-1 in patients with squamous-cell carcinoma after treatment for one period were significantly lower than those of patients before chemotherapy [1.67(0.04-218.60)U/L vs 4.75(0.05-226.30)U/L,2.12(0.12-20.65)μg/L vs 4.07(0. 11-40.21)μg/L](P ＜ 0.01).The levels of CK-2G2 and Cyfra21-1 in patients with progressive disease after treatment for one period were significantly higher than those of patients before chemotherapy(P ＜ 0.01).The levels of CK2G2 and Cyfra21-1 in patients with stable disease and partial remission after treatment for one period were significantly lower than those of patients before chemotherapy(P ＜ 0.01).There were no significant changes of the levels of CK-2G2 and Cyfra21-1 in patients after treatment for two periods compared with patients after treatment for one period(P ＞ 0.05).Conclusion The tumor markers CK-2G2 and Cyfra21-1 are valuable to monitor patients with non-small-cell lung cancer.
Keywords：Non-small-cell lung cancerTumor markerEfficacy
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)