Clinical research of echocardiography determining the endothelium function of coronary artery
LI Juan
CONG Yang
GUO Ying
TAN Yue-ping
Abstract：Objective To explore a way to determine endothelium function of coronary heart disease (CHD)by echocardiography combined with intervention experiment.Methods The control group consisted of 32 subjects with no risk factors for coronary artery disease; The observation group consisted of 26 subjects diagnosed of CHD by coronary arteriongraphy with coronary arteries stenosis more than 50％.All subjects were examined by echocardiography to record variation of the right coronary artery(RCA)diameter which responses to resting condition, cold pressor test and sublingual nitroglycerin.The changes of right coronary artery diameter were calculated.Results After cold pressor test,the increase rate of diameter in control group was more significant than that in observation group[(24.3± 1.4)％ vs(7.7 ± 1.0)％,P ＜ 0.01]; there was no significant difference about the increase rate of diameter between control group and observation group after nitroglycerin.Conclusions Patients with CHD can have the coronary endothelium-dependent dilatation,which can distinguish patients with CHD and patients without CHD in coronary endothelium function.This method can be conveniently used to evaluate endothelium function by echocardiogram.
Keywords：Coronary artery diseaseEndotheliumvascularEchocardiography
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)