The application of propofol target-controlled infusion during electrocorticography monitoring in epilepsy surgery
YANG Li-li
WANG Tian-long
TIAN Zhao-long
Abstract：Objective To discuss the feasibility of small doses of target control infusion propofol during electrocorticography (ECoG).Methods Forty patients were enrolled in this doubled -blind and prospective study.Patients were randomly divided into two groups (n =20 each):target-controlled infusion (TCI)(group A)and group stopping TCI (group B).Twenty minutes before the beginning of the ECoG,the target plasma concentration of propofol was changed to 1 mg/L in group A and the target plasma concentration of propofol was changed to 0 mg/L in group A.The incidence rate of choke cough,restless and awareness was recorded and compared.Results The time from drug withdrawal to carrying out ECoG successfully in group A and group B had no significant difference [ (27±7 )min vs (27±5 )min ].There was no cough and restless in two groups.There were 2/20 cases of intraoperative awareness in group A.There was no occurrence of intraoperative awareness in group B.Conclusions During ECoG monitoring,target controlled infusion of small doses of propofol(1 mg/L)will not affect the ECoG monitoring and can reduce intraoperative awareness incidence.TCI of small doses of propofol (1 mg/L)can be used as a suitable choice for the patients undergoing epileptic foci resection.
Keywords：EpilepsyPropofolElectrocorticographyTarget-controlled infusion
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)