Refluence of atorvastatin statins on inflammatory cytokine and nerve function detect of patients with acute cerebral infarction
WANG Jian-fa
JIA Shuai
Abstract：Objective To observe the refluence of atorvastatin statins on serum levels of high sensitivity C reaction protein (hs-CRP),interleukin (IL)-6,IL-10,endothelin-1 (ET-1)and the nerve function defect of patients with acute cerebral infarction.Methods All 86 patients with acute cerebral infarction for the first time were randomly divided into atorvastatin group (43 cases)and control group (43 eases).The control group received conventional therapy and the atorvastatin group received atorvastatin 10 mg/d on the basis of conventional therapy.The course of treatment was 30 days.In the first day of hospitalization and after treatment for 30 days,serum hs-CRP,IL-6,IL-10 and ET-lvalue were detected respectively,and the National Insititute of Health Stroke Scale(NIHSS)score and Barthel index scores were performed.Results Compared to before treatment,serum hs-CRP and IL-6 significantly decreased in atorvastatin group and control group after treatment for 30 days [atorvastatin group:(7.4±2.6)mg/L vs(12.1±5.3)mg/L,(9.4±1.8)μg/L vs(20.3±6.8)μg/L;control group:(9.4±3.6)mg/L vs(13.4±4.8)mg/L,(15.4±4.6)μg/L vs(22.7±6.7)μg/L],IL-10 increased significantly [ atorvastatin group:(9.4±3.1 )μg/L vs(3.1±0.5)μg/L;control group:(4.6±1.8)μg/L vs(2.7±0.4)μg/L],and ET-1 decreased [ atorvastatin group:(68±16)μg/L vs(89±20)μg/L;control group:(84±19)μg/L vs(92±21 )μg/L ],and there were significant differences (all P＜0.01 ).30 days after treatment,compared with the control group,the levels of hs-CRP,IL-6,ET-1 in atorvastatin group decreased,IL-10 increased (all P ＜0.01 ).Three months after onset,compared to before treatment,the scores of NIHSS in atorvastatin group and control group decreased [ (2.0±1.7 )scores va (4.2±2.3 )scores,(2.5±1.9 )scores vs (4.3±2.2 )scores,respectively],and the scores of Barthel index increased [ (95±6)scores vs (50±10)scores,(95±8)scores vs(58±12)scores] (all P ＜0.01 ).Compared with control group,there was no significant difference in NIHSS scores and Barthel index scores in atorvastatin group(all P ＞ 0.05).Conclusion Atorvastatin have cerebral protective effects,which can help the recovery of nerve function after cerebral infarction and can improve atherosclerotic plaque stability.
Keywords：Acute cerebral infarctionAtorvastatin statinsNerve functionHigh sensitive C reactive protein
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)