Effect observation of high branched-chain combined enteral nutrition on patients with acute severe craniocerebral trauma early by amino acids

LIAN Kun; SUN Hai-song; XU Wei; PU Jun; ZHAO Ning-hui

doi:10.3760/cma.j.issn.1673-4777.2012.09.013

Abstract：Objective To investigate the effects of early amino acids of high branched-chain combined enteral nutrition on patients with acute severe craniocerebral trauma.Methods Thirty-nine patients with acute severe craniocerebral trauma were randomly divided into control group (n =19)and observation group (n =20).The patients in the two groups received enteral nutrition (RuiSu)within 24 to 48 h after injury.While the patients in observation group also received high branched-chain 20AA compound amino acid injection;the patients in control group received common 18AA compound amino acid injection.The changes of ALT,AST,serum prealbumin and transferrin before and after treatment were observed,also the difference of infectious complications in two groups was observed.Results The levels of alanine aminotransferase and aspartate aminotransferase after treatment for 7 days in observation group were lower than those in control group [ (78±12 )U/L vs (96±12)U/L,(88±11 )U/L vs (107±14)U/L ];the level of serum prealbumin in observation group was higher than that in control group [(0.35±0.04)g/L vs(0.31±0.03)g/L];there was a significant difference between two groups (all P＜0.05).The incidence of infectious complications in observation group was lower than that in control group [ 30.0％ (6/20 )vs 42.1％ (8/19 )],but there was no significant difference (P ＞0.05).The duration of infection in observation group was less than that in control group [(7.6±0.8)d vs (8.8±1.3)d,P＜0.05].Conclusion Compared with early enteral nutrition combined with common 18AA compound amino acid injection,enteral nutrition combined with high branched-chain 20AA compound amino acid injection is more effective for the recovery of cellular immune function and for reducing the incidence of infectious complications in patients with acute severe craniocerebral trauma.